OCEG: Research (Mechano-Electric Feedback) 50,052 visitors
(Since May 17, 2005)
Home
Calendar
Research
Modelling
Mechano-Electric Feedback
Teaching
Contacts
Events
Links
Search
Site Map
General Information
The cardiac Mechano-Electric Feedback lab was established in 1998, primarily on the basis of support from the British Heart Foundation(Offsite...). Current members of the MEF team include Christian Bollensdorff (BHF(Offsite...) Research Scientist), Patrizia Camelliti (BBSRC(Offsite...) Research Scientist), Patricia Cooper (MRC(Offsite...) Research Scientist), Alan Garny (BBSRC(Offsite...) Research Scientist), Gentaro Iribe, and Rebecca Rowland (MRC(Offsite...) Research Assistant).
The MEF lab is led by Peter Kohl, Royal Society(Offsite...) University Research Fellow and a Principal Investigator in the newly founded Medical Research Council 'Cardiac Metabolic Electrophysiology' co-operative group at Oxford.
Research Interests
Our research interest is focused around the effects of mechanical stimulation on the regulation of heart rate and rhythm. Any regulatory process requires the presence of two principal directions of information exchange: 'top-down' control and bottom-up' feedback. In the case of the heart, control is by an electrical process called excitation, that co-ordinates contraction. This has traditionally been well investigated. The feedback, however, from the mechanical environment to the electrical control process - mechano-electric feedback - is much less well studied. Our work is directed on trying to shed light on the cellular basis of MEF in the heart, including the role of connective tissue in this process (for more information, see Research Projects & Publications)
Research Projects
(Item...) Mechanical modulation of heart rate: role of sino-atrial node pacemaker cells and fibroblasts. (BHF(Offsite...))
(Item...) Mechanical modulation of action potential shape: primary and secondary mechanisms. (BHF(Offsite...))
(Item...) Passive and active effects of fibrosis on post-ischaemic arrhythmogenesis. (MRC(Offsite...))
(Item...) Engineering Virtual Tissues and Organs. (EPSRC(Offsite...))
(Item...) Origin and propagation of cardiac excitation in a comprehensive anatomico-physiological computer model. (BIF(Offsite...))
(Item...) Action potential initiation and propagation in human atrium. (Wellcome(Offsite...))
Research Publications
(Item...) Publications(Offsite...)
Links
(Item...) University of Leeds: Dr Ed White(Offsite...)
(Item...) State University of New York, Buffalo: Prof. Fred Sachs(Offsite...)
University of Oxford(Offsite...)/Department of Physiology, Anatomy & Genetics(Offsite...)/Oxford Cardiac Electrophysiology Group/Research/Mechano-Electric Feedback
©2000-2012 Oxford Cardiac Electrophysiology Group. All rights reserved. Last revised on March 13, 2008, Webmaster